Sure, a good bunch are (looks like 20% to 50%, depending on your percentile chosen).
But the Cryptopunks are, generative and a collectible yes, but by all accounts a labour of love, an experiment before its time, given away for free at a time when no one gave a damn; it's not exactly the mass-production story you suggest.
Even if you buy wholesale into the narrative about the history of cryptopunks (and to be clear, this is a deliberately chosen narrative, the cryptopunk creators were not against making money and they gave away a large percentage of their tokens in part because they hoped the tokens they held would increase in value if they became more popular) -- but even if you take everything about their history at face value, you're still left with:
A) Pieces that do not have much artistic value outside of their position and relevance inside the ecosystem in which they were created: nobody is going to seriously claim that cryptopunks are themselves great works of art, any artistic value comes from the creation of the NFT model for generative/mass-produced artwork,
B) Pieces that are definitively mass-produced by design, and that served as a template for how other mass-produced collections could work,
C) Pieces that have been largely divorced from any artistic message that the original pieces held; the evolution of a piece designed to evoke a counter-cultural punk aesthetic into a piece that can only be controlled and owned by the richest members of society is its own possibly unintentional statement on the state of NFTs, and
D) Pieces that are significant specifically because they formed a model for other even more derivative pieces by other creators who lack even the benefit of imagination about the crypto-ecosystem itself. Cryptopunks are significant because they proved the viability of other collections like bored apes and their ilk, products that are entirely devoid of any kind of meaningful social statement or craftmanship. And one has to wonder what the actual artistic value or craftmanship is in building that model and why we should be impressed with the creators behind it.
And even if you're optimistic about all of this and think the pieces are genuinely significant and meaningful, you still wouldn't compare cryptopunks to a hand-crafted watch. They're at best historically significant, but they don't demonstrate any particularly breathtaking artistic skill, and any artistic message they were trying to make has been largely invalidated by the evolution of the space into the least "punk" community in tech. The nicest thing I can say about cryptopunks is that they have inadvertently turned into an effective satire of what the NFT community thinks about itself.
Then how many of the highest-selling NFTs of all time are cryptopunks?